She was the daughter of Lyman and Roxana Beecher and married Professor Calvin E. Stowe.
A famous writer, her Uncle Tom's Cabin appeared as a serial in the National Era, an antislavery paper published by Gamaliel Bailey and John G. Whittier in June 1851. At the time it was published in book form (1852), Stowe moved to Andover, MA and the following year went abroad. In 1864 she removed to Hartford, CT, where she continued her writing.
Her publications included: A Key to Uncle Tom's Cabin (1853); A Peep into Uncle Tom's Cabin for Children (1853); Sunny Memories of Foreign Lands (1854).
Phebe Hanaford, Daughters of America; or Women of the Century, Augusta, 1882, p. 201; John R. Adams, Harriet Beecher Stowe, New York, 1963; Alice Cooper Crozier, The Novels of Harriet Beecher Stowe, New York, 1969.