He was the son of Benjamin Henry and Mary E. (Hazlehurst) Latrobe.
He graduated from St Mary's college, Baltimore, MD, in 1825, was admitted to the bar, and practised in Baltimore with his brother John. He worked for the Baltimore and Ohio Railroad Company as first assistant to the Chief-Engineer Jonathan Knight and for twenty-two years held the position of chief engineer. It was at this time that he met George Washington Whistler (AMW's husband).
He built the road from Harper's Ferry to Wheeling and supervised the construction of the road from Cumberland to the Ohio River. He was consulting engineer of the Hoosac tunnel and a member of the advisory board of the Brooklyn Bridge.
Who Was Who in America, Chicago, 1963, p. 305; Dictionary of American Biography.